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GLP-1 receptor agonist counselling — GPhC CRA MCQ

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HardEndocrine TherapeuticsGLP-1 receptor agonist counsellingGPhC CRA

A patient who injects semaglutide every Monday realises on Thursday that this week’s dose was missed. The next dose is due in four days. What should they do?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Take the missed dose now and then resume the usual Monday schedule

Take the missed dose now and then resume the usual Monday schedule: A missed semaglutide dose may be administered within five days; the usual weekly schedule can then be resumed. Skip it because any delay beyond 24 hours makes the dose unsafe: The UK product information permits administration within five days. Take two doses together next Monday to maintain the monthly total: Dose doubling increases adverse effects and is not recommended. Take half a dose now and half on Monday: Partial dosing is not the licensed missed-dose instruction. Restart the full initiation titration after every single missed dose: One dose missed within the permitted window does not automatically require complete re-titration.

Reference: Ozempic UK summary of product characteristics: https://www.medicines.org.uk/emc/product/9750/smpc; BNF: semaglutide: https://bnf.nice.org.uk/drugs/semaglutide/