skip to main content

SSRI and tramadol — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

ModerateDrug InteractionsSSRI and tramadolGPhC CRA

A patient taking sertraline is prescribed tramadol for back pain. He has a history of epilepsy documented in the pharmacy record. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — Tramadol with sertraline can increase serotonin syndrome and seizure risk

Tramadol has serotonergic activity and can lower seizure threshold. Combined use with an SSRI increases concern for serotonin syndrome, and epilepsy adds further risk. The pharmacist should query the prescription and discuss safer analgesia with the prescriber.

Reference: BNF