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Bisphosphonate administration — GPhC CRA MCQ

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HardMusculoskeletal TherapeuticsBisphosphonate administrationGPhC CRA

A woman starts alendronic acid 70mg once weekly for osteoporosis. She asks why the instructions are so specific. What would you advise the patient?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Take it with plain water after getting up and remain upright before food

Alendronic acid can cause oesophageal irritation and has poor absorption. It should be taken with plain water on waking, with the patient remaining upright and delaying food or other medicines as directed. Calcium or food taken at the same time can reduce absorption.

Reference: BNF; NICE CKS