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Edoxaban renal dosing — GPhC CRA MCQ

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EasyCardiovascular TherapeuticsEdoxaban renal dosingGPhC CRA

A community pharmacist checks a prescription for edoxaban 60mg once daily for atrial fibrillation. The patient's recent creatinine clearance in the discharge letter is 32mL/min. What monitoring is required?

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Correct answer: C — Query whether a reduced edoxaban dose is required

Edoxaban dosing depends on renal function and other factors such as weight and interacting medicines. A creatinine clearance of 32mL/min may require dose reduction, so the pharmacist should query before dispensing. The pharmacist should not independently change the prescribed dose or add antiplatelet therapy.

Reference: BNF