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Linezolid and SSRI — GPhC CRA MCQ

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EasyDrug InteractionsLinezolid and SSRIGPhC CRA

A hospital discharge prescription includes linezolid for a resistant infection. The patient is taking fluoxetine and asks whether to restart it today. What is the most important interaction to flag?

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Correct answer: E — Linezolid with fluoxetine can increase serotonin syndrome risk

Linezolid has monoamine oxidase inhibitor activity and can interact with serotonergic medicines. Combining it with fluoxetine can increase serotonin syndrome risk, and fluoxetine has a long half-life. Specialist or prescriber advice is needed before restarting.

Reference: BNF