H. pylori therapy interaction — GPhC CRA MCQ
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Correct answer: E — Both antibiotics can increase anticoagulant effect and bleeding risk
Clarithromycin and metronidazole can increase the effect of warfarin and raise bleeding risk. The prescriber or anticoagulation clinic should be informed so INR monitoring and treatment choice can be managed. The interaction is clinically important and should not be ignored.
Reference: BNF