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Methotrexate monitoring — GPhC CRA MCQ

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HardMusculoskeletal TherapeuticsMethotrexate monitoringGPhC CRA

A patient on methotrexate for psoriasis asks which tests are needed before the next repeat prescription. The dose was increased four weeks ago. What monitoring is required?

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Correct answer: B — Full blood count, liver function, and renal function

Methotrexate can cause bone marrow suppression, hepatotoxicity, and renal-related toxicity. Full blood count, liver function, and renal function monitoring are central, especially after dose changes. Other tests may be needed for individual patients but are not the core routine monitoring set.

Reference: BNF; NICE CKS; SPS