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Amitriptyline overdose risk — GPhC CRA MCQ

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ModerateCNS TherapeuticsAmitriptyline overdose riskGPhC CRA

A patient with depression and a history of self-harm presents a new prescription for amitriptyline 50mg tablets. The quantity prescribed is 100 tablets. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Query the quantity with the prescriber before dispensing

Tricyclic antidepressants can be dangerous in overdose. Where there is a known risk of self-harm, the quantity supplied should be considered carefully and discussed with the prescriber if needed. The pharmacist should balance access to treatment with patient safety.

Reference: BNF; GPhC Standards