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Methotrexate weekly dosing — GPhC CRA MCQ

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HardMusculoskeletal TherapeuticsMethotrexate weekly dosingGPhC CRA

A patient with rheumatoid arthritis presents a prescription for methotrexate 10mg tablets with directions stating take 10mg daily. The patient says it is normally taken on Mondays. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Do not dispense until the dose frequency is clarified with the prescriber

Methotrexate for inflammatory disease is usually taken once weekly, and daily dosing errors can be fatal. A direction that conflicts with the patient's usual weekly regimen must be clarified before supply. The pharmacist should also reinforce the weekly dosing day and folic acid instructions.

Reference: BNF; NICE CKS