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Oral contraceptive and lamotrigine — GPhC CRA MCQ

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EasyDrug InteractionsOral contraceptive and lamotrigineGPhC CRA

A patient taking lamotrigine for epilepsy starts a combined oral contraceptive. She asks whether her seizure control could be affected. What is the most important interaction to flag?

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Correct answer: B — Combined hormonal contraception can reduce lamotrigine levels

Oestrogen-containing contraception can reduce lamotrigine concentrations and may affect seizure control. Starting or stopping combined hormonal contraception may require specialist review and dose adjustment. The pharmacist should advise the patient to contact the prescriber or epilepsy team.

Reference: BNF; FSRH