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SSRI and NSAID — GPhC CRA MCQ

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ModerateDrug InteractionsSSRI and NSAIDGPhC CRA

A patient taking citalopram asks to buy ibuprofen for dental pain. She has a history of peptic ulcer disease. What is the most important interaction to flag?

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Correct answer: B — The combination can increase gastrointestinal bleeding risk

SSRIs can increase bleeding risk, and NSAIDs add gastrointestinal bleeding risk, especially with previous ulcer disease. The pharmacist should consider safer analgesia and advise dental or medical review as needed. Gastroprotection and prescriber input may be needed if NSAID therapy is unavoidable.

Reference: BNF