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Montelukast neuropsychiatric effects — GPhC CRA MCQ

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HardRespiratory TherapeuticsMontelukast neuropsychiatric effectsGPhC CRA

A parent says their 9-year-old has developed nightmares and mood changes after starting montelukast for asthma. The parent asks whether this could be related. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Advise contacting the prescriber promptly to review montelukast

Montelukast has been associated with neuropsychiatric reactions including sleep disturbance and mood changes. The prescriber should review whether treatment should continue and whether alternative asthma management is needed. Increasing the dose or adding sedating treatment would not address the safety concern.

Reference: BNF; MHRA