A NovoRapid FlexPen was accidentally placed against a freezer plate overnight. It is now thawed, the solution is clear and the pen is within its

Question

A NovoRapid FlexPen was accidentally placed against a freezer plate overnight. It is now thawed, the solution is clear and the pen is within its expiry date. What should the pharmacist advise?

Accepted Answer

Do not use it; frozen insulin must be replaced even if it has thawed and looks normal

Answer

Warm it in hot water and administer a doubled first dose

Answer

Return it to the refrigerator for 24 hours to reverse freeze damage

Answer

Use only for correction doses because freezing affects basal insulin more than rapid insulin

Answer

Use it after rolling the pen because clarity proves biological activity

Insulin storage — GPhC CRA MCQ

A NovoRapid FlexPen was accidentally placed against a freezer plate overnight. It is now thawed, the solution is clear and the pen is within its expiry date. What should the pharmacist advise?