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Spironolactone hyperkalaemia in CKD — GPhC CRA MCQ

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HardRenal and Hepatic ImpairmentSpironolactone hyperkalaemia in CKDGPhC CRA

A person with CKD takes ramipril and spironolactone. Potassium is 5.9 mmol/L on a result issued today, and a repeat prescription is awaiting collection. What should the pharmacist do?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Pause routine supply and obtain same-day clinical assessment

CKD and combined renin–angiotensin–aldosterone blockade increase hyperkalaemia risk. A potassium of 5.9 mmol/L warrants same-day clinical review before routine continuation; the clinician will consider repeat testing, ECG or acute treatment and which medicines to withhold.

Reference: BNF: spironolactone: https://bnf.nice.org.uk/drugs/spironolactone/