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Lithium and ACE inhibitor — GPhC CRA MCQ

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HardDrug InteractionsLithium and ACE inhibitorGPhC CRA

A patient taking lithium is newly prescribed lisinopril for hypertension. The pharmacy system flags an interaction and the patient is due to collect both medicines. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Lisinopril can increase lithium levels and toxicity risk

ACE inhibitors can increase lithium concentrations and risk of toxicity. If the combination is clinically necessary, lithium levels and renal function need close monitoring and patient counselling on toxicity symptoms. The prescriber should be contacted to confirm the plan.

Reference: BNF