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Digoxin and amiodarone — GPhC CRA MCQ

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ModerateDrug InteractionsDigoxin and amiodaroneGPhC CRA

A patient taking digoxin for atrial fibrillation is newly prescribed amiodarone. The pharmacy record shows previous digoxin toxicity. What is the most important interaction to flag?

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Correct answer: E — Amiodarone can increase digoxin levels and toxicity risk

Amiodarone can increase digoxin concentrations and bradycardia risk. The prescriber should consider dose reduction and monitoring where appropriate. Previous toxicity makes the interaction especially important to flag.

Reference: BNF