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Clopidogrel and fluoxetine — GPhC CRA MCQ

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ModerateDrug InteractionsClopidogrel and fluoxetineGPhC CRA

A patient taking clopidogrel after a stroke is prescribed fluoxetine for depression. The pharmacist notices no discussion of antiplatelet therapy. What is the most important interaction to flag?

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Correct answer: B — Fluoxetine may reduce clopidogrel activation and increase bleeding risk

Fluoxetine can inhibit CYP2C19, which may reduce clopidogrel activation, and SSRIs can also increase bleeding risk. The prescriber should consider the interaction and alternative antidepressants if appropriate. The patient should not stop either medicine without advice.

Reference: BNF