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Pancreatic enzyme counselling — GPhC CRA MCQ

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HardGastrointestinal TherapeuticsPancreatic enzyme counsellingGPhC CRA

A patient with pancreatic exocrine insufficiency is prescribed three pancreatin capsules with a prolonged main meal and one with snacks. Which plan best optimises enzyme–food mixing?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Begin with the first mouthful and distribute capsules through meals and snacks

Pancreatic enzymes need to mix with food entering the gut. The first capsule should be taken with the first mouthful and, when several are prescribed, the remainder should be distributed through the meal. Prescribed snack doses also matter. Taking the dose well before, only after, at bedtime or as one daily bolus reduces synchrony with food.

Reference: Cambridge University Hospitals: Pancreatic enzyme replacement therapy: https://www.cuh.nhs.uk/patient-information/information-for-people-taking-pancreatic-enzymes-for-pancreatic-insufficiency/