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MAOI interaction — GPhC CRA MCQ

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HardCNS TherapeuticsMAOI interactionGPhC CRA

A patient taking phenelzine for depression asks to buy pseudoephedrine tablets for nasal congestion. He has no other acute symptoms. What is the most important interaction to flag?

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Correct answer: E — Pseudoephedrine with phenelzine can cause a dangerous hypertensive reaction

Monoamine oxidase inhibitors can interact seriously with sympathomimetics such as pseudoephedrine. The interaction can lead to marked hypertension and should be avoided. Safer non-systemic options and prescriber advice should be considered.

Reference: BNF