skip to main content

SSRI and MAOI — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardDrug InteractionsSSRI and MAOIGPhC CRA

A patient who stopped phenelzine eight days ago presents a prescription for fluoxetine. He says the GP was unsure about the washout period. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Query the prescription because a suitable washout period is needed

Combining or closely sequencing MAOIs and SSRIs can cause serious serotonin toxicity. Washout periods are required and depend on the drugs involved. The prescriber should confirm the safe start date before supply.

Reference: BNF