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Clindamycin diarrhoea — GPhC CRA MCQ

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HardInfectionsClindamycin diarrhoeaGPhC CRA

A patient taking clindamycin for dental infection develops watery diarrhoea six times daily with abdominal cramps. He asks to buy loperamide. What is the most appropriate action?

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Correct answer: E — Refer urgently because antibiotic-associated colitis is possible

Clindamycin is associated with C. difficile infection and antibiotic-associated colitis. Significant diarrhoea with cramps during therapy warrants urgent medical advice, and antimotility agents may be inappropriate. The antibiotic plan should be reviewed.

Reference: BNF; NICE CKS