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Fluconazole and warfarin — GPhC CRA MCQ

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ModerateDrug InteractionsFluconazole and warfarinGPhC CRA

A patient stabilised on warfarin asks to buy oral fluconazole for thrush. She has noticed gum bleeding this week. What is the most important interaction to flag?

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Correct answer: A — Fluconazole can increase INR and bleeding risk

Fluconazole can inhibit warfarin metabolism and increase INR. Existing gum bleeding makes immediate assessment more important. The anticoagulation clinic or prescriber should advise before use.

Reference: BNF