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Theophylline interaction — GPhC CRA MCQ

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ModerateRespiratory TherapeuticsTheophylline interactionGPhC CRA

A patient taking theophylline MR for COPD presents a prescription for ciprofloxacin. He has had nausea with theophylline before. What is the most important interaction to flag?

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Correct answer: A — Ciprofloxacin can increase theophylline levels and toxicity risk

Ciprofloxacin can increase theophylline concentrations and toxicity risk. Theophylline has a narrow therapeutic index and toxicity can include nausea, vomiting, arrhythmias and seizures. An alternative antibiotic or monitoring plan should be discussed.

Reference: BNF