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Amitriptyline in older person — GPhC CRA MCQ

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ModerateCNS TherapeuticsAmitriptyline in older personGPhC CRA

An 82-year-old woman is prescribed amitriptyline 25 mg at night for neuropathic pain. She has falls, constipation and glaucoma. What is the most appropriate alternative?

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Correct answer: C — Discuss a safer neuropathic pain option with the prescriber

Amitriptyline has anticholinergic and sedating effects that can worsen falls, constipation and glaucoma. Older patients are particularly susceptible. The pharmacist should query suitability and discuss alternatives such as duloxetine or gabapentinoids where appropriate.

Reference: BNF; NICE CKS