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Valproate and lamotrigine — GPhC CRA MCQ

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HardDrug InteractionsValproate and lamotrigineGPhC CRA

A patient established on sodium valproate is newly prescribed lamotrigine. The dose appears higher than the titration schedule used locally. What is the most important interaction to flag?

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Correct answer: E — Valproate increases lamotrigine exposure and rash risk

Valproate inhibits lamotrigine metabolism, increasing lamotrigine concentrations and risk of serious rash. Lamotrigine requires careful titration, especially with valproate. The prescription should be checked before supply.

Reference: BNF