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Statin rhabdomyolysis — GPhC CRA MCQ

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HardAdverse Drug Reactions and Drug SafetyStatin rhabdomyolysisGPhC CRA

A 66-year-old man on atorvastatin develops severe muscle pain, weakness and dark urine after starting clarithromycin abroad. What is the most appropriate action?

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Correct answer: D — Stop the statin and seek urgent medical assessment for rhabdomyolysis

Severe muscle symptoms with dark urine may indicate rhabdomyolysis, especially after interacting medicines such as macrolides. Urgent assessment including CK and renal function is needed. Continuing the statin could worsen harm.

Reference: BNF