skip to main content

Nitrate and PDE5 inhibitor — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

EasyCardiovascular TherapeuticsNitrate and PDE5 inhibitorGPhC CRA

A 62-year-old man using isosorbide mononitrate MR for angina asks for advice about sildenafil obtained online. He has stable angina and uses GTN spray occasionally. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Sildenafil with nitrates can cause severe hypotension

PDE5 inhibitors such as sildenafil are contraindicated with nitrates because the combination can cause profound hypotension. This applies to regular nitrates and acute nitrate preparations such as GTN. The patient should be advised not to combine them and to seek prescriber advice.

Reference: BNF