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Linezolid and SSRI — GPhC CRA MCQ

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HardCNS TherapeuticsLinezolid and SSRIGPhC CRA

A hospital outpatient taking paroxetine is prescribed linezolid for a resistant skin infection. The pharmacist notices both medicines on the discharge summary. What is the most important interaction to flag?

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Correct answer: B — Linezolid with paroxetine can cause serotonin syndrome

Linezolid has monoamine oxidase inhibitor activity and can interact with serotonergic antidepressants. The combination can precipitate serotonin syndrome. The prescriber should confirm the plan and monitoring or consider alternatives.

Reference: https://www.pharmacyregulation.org/registration-assessment#stage-8-order-26