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Methadone and QT prolongation — GPhC CRA MCQ

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HardDrug InteractionsMethadone and QT prolongationGPhC CRA

A 39-year-old man on methadone maintenance is prescribed citalopram for depression. He has a previous ECG showing prolonged QT interval. What is the most important interaction to flag?

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Correct answer: E — Additive QT prolongation risk

Methadone and citalopram can both prolong the QT interval. Previous QT prolongation increases arrhythmia risk and warrants prescriber review. Alternative antidepressant selection or ECG monitoring may be needed.

Reference: BNF