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Tramadol and SSRI — GPhC CRA MCQ

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ModerateCNS TherapeuticsTramadol and SSRIGPhC CRA

A patient taking fluoxetine for depression is prescribed tramadol for acute back pain. She has a history of seizures. What is the most important interaction to flag?

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Correct answer: D — Raised risk of serotonin syndrome and seizures

Tramadol has serotonergic activity and can lower seizure threshold. Combining it with an SSRI such as fluoxetine increases the risk of serotonin syndrome and seizures. An alternative analgesic should be considered.

Reference: BNF