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Amlodipine adverse effect — GPhC CRA MCQ

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ModerateCardiovascular TherapeuticsAmlodipine adverse effectGPhC CRA

A 66-year-old woman started amlodipine 10 mg daily four weeks ago. She reports bilateral ankle swelling but has no breathlessness and her weight is unchanged. Her BP is now controlled. What is the most appropriate alternative?

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Correct answer: B — Discuss dose reduction or an alternative antihypertensive with the prescriber

Peripheral oedema is a recognised dose-related adverse effect of dihydropyridine calcium-channel blockers. It is not fluid overload and adding a diuretic is usually unhelpful. A dose reduction or switching treatment should be discussed with the prescriber.

Reference: BNF; NICE CKS