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Clopidogrel and PPI choice — GPhC CRA MCQ

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ModerateCardiovascular TherapeuticsClopidogrel and PPI choiceGPhC CRA

A 72-year-old woman takes clopidogrel after a TIA and is prescribed omeprazole for dyspepsia. The GP asks whether this is appropriate. What is the most appropriate alternative?

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Correct answer: E — Use lansoprazole or pantoprazole if a PPI is required

Omeprazole can inhibit CYP2C19 and may reduce activation of clopidogrel. If a PPI is needed, alternatives such as lansoprazole or pantoprazole are generally preferred. Separating administration times does not reliably avoid the metabolic interaction.

Reference: BNF