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SSRI and NSAID bleeding — GPhC CRA MCQ

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ModerateCNS TherapeuticsSSRI and NSAID bleedingGPhC CRA

A 70-year-old woman takes sertraline and asks to buy naproxen for back pain. She has a history of peptic ulcer disease. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Sertraline and naproxen can increase gastrointestinal bleeding risk

SSRIs can increase bleeding risk, and NSAIDs further increase gastrointestinal bleeding risk. Previous peptic ulcer disease makes this more clinically significant. Safer analgesia or prescriber review should be considered.

Reference: BNF