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Colchicine macrolide interaction — GPhC CRA MCQ

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ModerateMusculoskeletal TherapeuticsColchicine macrolide interactionGPhC CRA

A patient taking colchicine for gout is prescribed clarithromycin for pneumonia. He has CKD stage 3. What is the most important interaction to flag?

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Correct answer: E — Clarithromycin can increase colchicine toxicity risk

Clarithromycin can inhibit colchicine metabolism and transport, increasing toxicity risk. Renal impairment further raises risk. The combination should be avoided or managed with specialist advice.

Reference: BNF