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Clozapine infection symptoms — GPhC CRA MCQ

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HardCNS TherapeuticsClozapine infection symptomsGPhC CRA

A patient taking clozapine phones saying he has a sore throat, fever and mouth ulcers. He asks for chlorhexidine mouthwash. What is the most appropriate action?

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Correct answer: B — Advise urgent same-day blood count and clinical assessment

Clozapine can cause neutropenia and agranulocytosis. Fever, sore throat and mouth ulcers require urgent blood count and medical assessment. Treating symptoms without assessment could miss a serious adverse reaction.

Reference: BNF