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Azole and DOAC — GPhC CRA MCQ

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HardDrug InteractionsAzole and DOACGPhC CRA

A patient taking rivaroxaban for AF is prescribed itraconazole capsules for fungal infection. He has CKD stage 3. What is the most important interaction to flag?

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Correct answer: B — Itraconazole can increase rivaroxaban exposure and bleeding risk

Itraconazole can inhibit CYP3A4 and P-glycoprotein, increasing exposure to rivaroxaban. CKD and anticoagulation increase the clinical significance. The prescriber should consider alternative antifungal or anticoagulant management.

Reference: BNF