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Clarithromycin and colchicine — GPhC CRA MCQ

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HardDrug InteractionsClarithromycin and colchicineGPhC CRA

A 69-year-old man taking colchicine for gout prophylaxis is prescribed clarithromycin. He also has reduced renal function. What is the most important interaction to flag?

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Correct answer: E — Increased colchicine toxicity risk

Clarithromycin can increase colchicine exposure through CYP3A4 and P-glycoprotein inhibition. Renal impairment increases the risk of severe toxicity. The prescriber should consider an alternative antibiotic or hold/adjust therapy with specialist input.

Reference: BNF