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Lamotrigine rash — GPhC CRA MCQ

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HardCNS TherapeuticsLamotrigine rashGPhC CRA

A 30-year-old woman started lamotrigine for epilepsy three weeks ago. She phones the pharmacy because she has developed a widespread rash and fever. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Advise urgent medical assessment and not to take further doses until reviewed

Lamotrigine can rarely cause serious skin reactions, especially early in treatment. Rash with systemic features such as fever requires urgent assessment. Continuing or increasing the dose without review would be unsafe.

Reference: BNF