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Topiramate pregnancy prevention — GPhC CRA MCQ

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HardAdverse Drug Reactions and Drug SafetyTopiramate pregnancy preventionGPhC CRA

A 27-year-old woman taking topiramate for migraine asks for a repeat prescription and says she is not using contraception. She may try for pregnancy soon. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Supply with urgent prescriber review and pregnancy prevention counselling as required

Topiramate has important pregnancy safety restrictions because of fetal harm risks. Women of childbearing potential need appropriate counselling, pregnancy prevention measures and prescriber review. Abrupt cessation may be unsafe depending on indication.

Reference: BNF; MHRA Drug Safety Update