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NSAID and asthma — GPhC CRA MCQ

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HardMusculoskeletal TherapeuticsNSAID and asthmaGPhC CRA

A 46-year-old with asthma and nasal polyps developed wheeze and facial flushing within 30 minutes of taking aspirin. She asks whether topical ibuprofen gel is safe for a sprained wrist because it is “not swallowed”. What is the best advice?

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Correct answer: C — Avoid oral and topical non-selective NSAIDs

Asthma, nasal polyps and an immediate respiratory reaction to aspirin strongly suggest NSAID-exacerbated respiratory disease. Cross-reactive bronchospasm can occur with non-selective NSAIDs, and SPS includes both oral and topical preparations in its avoidance advice for people with a previous NERD reaction. Another analgesic can be considered after checking suitability and assessing the injury.

Reference: NHS SPS: Using NSAIDs in asthma: https://sps.nhs.uk/articles/using-nsaids-in-asthma/