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PPI and mycophenolate — GPhC CRA MCQ

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HardDrug InteractionsPPI and mycophenolateGPhC CRA

A transplant patient taking mycophenolate mofetil is prescribed lansoprazole for reflux symptoms. The specialist letter asks the pharmacy to check interactions. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Check with the transplant team because acid suppression may affect mycophenolate exposure

Acid-suppressing therapy can affect exposure to some mycophenolate formulations, and transplant patients are high risk. The transplant team should guide management where there is uncertainty. Pharmacists should avoid unauthorised changes to immunosuppression.

Reference: BNF