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Folic acid with methotrexate — GPhC CRA MCQ

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EasyMusculoskeletal TherapeuticsFolic acid with methotrexateGPhC CRA

A 54-year-old woman taking weekly methotrexate asks why she also takes folic acid on a different day. What would you advise the patient?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Folic acid helps reduce methotrexate adverse effects

Folic acid is commonly prescribed with low-dose methotrexate to reduce adverse effects such as mouth ulcers and gastrointestinal symptoms. It does not replace routine monitoring for toxicity. The schedule should follow local/prescriber instructions.

Reference: BNF; NICE CKS