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LAMA antimuscarinic caution — GPhC CRA MCQ

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HardRespiratory TherapeuticsLAMA antimuscarinic cautionGPhC CRA

An 80-year-old with COPD and symptomatic prostatic enlargement starts aclidinium. Two days later he develops inability to pass urine and severe eye pain with blurred vision and coloured haloes. What is the most appropriate action?

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Correct answer: BWithhold aclidinium and arrange urgent assessment for urinary retention and angle-closure glaucoma

Aclidinium has antimuscarinic effects and requires caution in symptomatic prostatic hyperplasia, bladder-neck obstruction and narrow-angle glaucoma. Acute urinary retention and a painful red eye with visual haloes need urgent assessment; further doses should be withheld pending clinical review. Adding another antimuscarinic medicine could worsen both problems, and routine follow-up would be an unsafe delay.

Reference: Eklira Genuair 322 micrograms SmPC: https://www.medicines.org.uk/emc/product/14790/smpc