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Carbamazepine and DOAC — GPhC CRA MCQ

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HardDrug InteractionsCarbamazepine and DOACGPhC CRA

A 64-year-old man taking carbamazepine for epilepsy is newly prescribed apixaban for AF. What is the most important interaction to flag?

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Correct answer: B — Carbamazepine can reduce apixaban exposure and anticoagulant effect

Carbamazepine is a strong enzyme inducer and can reduce exposure to some DOACs, risking thrombosis. Anticoagulant choice should be reviewed by the prescriber. This is clinically important because the drug is used to prevent stroke in AF.

Reference: BNF