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Nitrofurantoin liver adverse effects — GPhC CRA MCQ

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HardRenal and Hepatic ImpairmentNitrofurantoin liver adverse effectsGPhC CRA

A woman has taken nitrofurantoin prophylaxis for recurrent UTI for several months and now reports persistent cough, breathlessness and jaundice. What is the most appropriate action?

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Correct answer: A — Stop and refer urgently for suspected pulmonary or hepatic toxicity

Long-term nitrofurantoin can rarely cause pulmonary and hepatic toxicity. Persistent respiratory symptoms and jaundice require urgent assessment and stopping pending review. Ongoing prophylaxis should be reviewed regularly.

Reference: BNF; MHRA Drug Safety Update