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Macrolide QT risk — GPhC CRA MCQ

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HardInfectionsMacrolide QT riskGPhC CRA

A patient taking citalopram 40 mg daily and amiodarone is prescribed clarithromycin. The GP asks whether there is a safety concern. What is the most important interaction to flag?

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Correct answer: C — Additive QT prolongation risk

Citalopram, amiodarone and clarithromycin can each contribute to QT prolongation. Combining QT-prolonging medicines increases the risk of serious arrhythmia, particularly in vulnerable patients. An alternative antibiotic should be considered.

Reference: BNF