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Morphine in renal impairment — GPhC CRA MCQ

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HardRenal and Hepatic ImpairmentMorphine in renal impairmentGPhC CRA

A 79-year-old man with eGFR 18 mL/min/1.73 m² is prescribed morphine sulfate oral solution for chronic breathlessness. He is opioid-naïve. What is the most appropriate action?

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Correct answer: B — Query the prescription because morphine metabolites can accumulate in renal impairment

Morphine active metabolites can accumulate in significant renal impairment, increasing sedation and respiratory depression risk. Specialist or prescriber review is needed for opioid choice and dose. Opioid-naïve patients require particular caution.

Reference: BNF