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Nitrofurantoin renal function — GPhC CRA MCQ

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ModerateInfectionsNitrofurantoin renal functionGPhC CRA

A 74-year-old woman is prescribed nitrofurantoin for lower UTI. Her recent eGFR is 28 mL/min/1.73 m². What is the most appropriate alternative?

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Correct answer: A — Query the prescription because renal function may make nitrofurantoin unsuitable

Nitrofurantoin requires adequate renal function to achieve urinary concentrations and avoid toxicity. An eGFR of 28 mL/min/1.73 m² makes routine use unsuitable in most cases. The prescriber should review antibiotic choice.

Reference: BNF; NICE CKS