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Morphine renal impairment — GPhC CRA MCQ

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HardRenal and Hepatic ImpairmentMorphine renal impairmentGPhC CRA

A palliative care patient with eGFR 18 becomes increasingly drowsy after morphine dose escalation. What is the most appropriate action?

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Correct answer: C — Advise urgent prescriber review because morphine metabolites can accumulate in renal impairment

Morphine metabolites can accumulate in renal impairment and cause toxicity. In this scenario, the pharmacist should prioritise safe supply, appropriate counselling and timely referral or clarification where needed. This is the single best answer because the other options would either delay assessment, ignore a clinically significant risk, or create an unsafe legal or professional outcome.

Reference: BNF