skip to main content

Methotrexate weekly dosing — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardMusculoskeletal TherapeuticsMethotrexate weekly dosingGPhC CRA

A patient collecting methotrexate 2.5 mg tablets for rheumatoid arthritis says the label reads 'take six tablets daily' but previous supplies were weekly. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Stop the supply and urgently clarify the prescription because methotrexate should be taken weekly for this indication

Daily low-dose methotrexate errors can be fatal and must be intercepted. In this scenario, the pharmacist should prioritise safe supply, appropriate counselling and timely referral or clarification where needed. This is the single best answer because the other options would either delay assessment, ignore a clinically significant risk, or create an unsafe legal or professional outcome.

Reference: BNF; MEP